RAF Typhoon jets have operated alongside French aircraft in a joint strike targeting an underground arms cache in Syria employed by the IS group, according to the British defence ministry.
The location, pinpointed through intelligence, was assessed as housing weapons and explosive materials, the release indicated, and was positioned in mountainous terrain just to the north of Palmyra in Syria's central region.
"Our aircraft utilized Paveway IV guided bombs to target a number of approach shafts providing entry to the site... preliminary assessments suggest the objective was successfully hit," the MoD said.
There was no evidence of any civilian impact in the operation conducted Saturday night and every plane involved returned to base without incident, the MoD added.
The Typhoon fighters were supported by a Voyager refuelling tanker.
IS - referred to as ISIS - enforced extremist governance over large swathes of both Syria and Iraq prior to its 2019 collapse.
"This action demonstrates the UK's leading role, and determination to stand shoulder to shoulder with allied nations, to eliminate any revival of Daesh and their violent and radical beliefs in the Middle East," the British Defence Secretary John Healey said.
RAF aircraft have performed surveillance missions over Syria to "deter any efforts to regroup" of IS following its routing at the battle of Baghuz in 2019, the MoD reported.
"I want to thank every member of the UK armed forces participating in this operation for their professionalism and their bravery," the Defence Secretary added. "Including them were a great many UK service members stationed over the holidays. This operation, to eliminate terrorist threats who endanger our security, demonstrates how British military are ready to step up, continuously, ensuring Britain's security at home and influential overseas."
Last December, the United States armed forces conducted what it described as a "major assault" targeting Daesh sites in Syria, subsequent to an assault killed two US troops and a local interpreter in Palmyra.
The United Nations reports Islamic State still boasts roughly 5-7 thousand combatants in both countries.